Ritalin Abuse and Drug Interactions

Ritalin Abuse and Drug Interactions

The prescription stimulant Ritalin (methylphenidate) can cause serious negative interactions when taken with other drugs. These reactions can occur even at therapeutic doses, and the higher doses associated with Ritalin abuse increase both the likelihood of adverse interactions as well as their potential severity.

Drugs with Major Interactions with Ritalin

Drugs that are known to have serious negative interactions with Ritalin include the following drugs that should not be taken with Ritalin (listings are of the generic drugs with brand names in parentheses and with interaction effects after):

  • Acetaminophen/tramadol (Tramap ap, Ultracet); increases the risk of seizures if taken with Ritalin
    Bisacodyl/sodium phosphate/sodium biphosphate (Fleet Prep Kit 1, Fleet Prep Kit 2, Fleet Prep Kit 3); many enema and bowel cleansing preparations are associated with a risk of seizures which is increased if taken with Ritalin
  • Bupropion (Aplenzin, Budeprion, Budeprion SR, Budeprion XL, Buprodan, Forfivo XL, Wellbutrin, Wellbutrin SR, Wellbutrin XL, Zyban); bupropion is associated with a risk of seizures which may be increased if taken with Ritalin
  • Furazolidone (Furoxone); taking monoamine oxidase inhibitors (MAOIs) with Ritalin may cause severe hypertension and possibly death
  • Hyoscyamine/methinamine/methylene blue/sodium biphosphate (Urogesic Blue); increased risk of seizures if taken with Ritalin
  • Iohexal (Myelo-kit, Omnipaque 140, Omnipaque 180, Omnipaque 180 Redi-Unit, Omnipaque 210, Omnipaque 240, Omnipaque 240 Redi-Unit, Omnipaque 300, Omnipaque 350, Omnipaque Flexipak); increased risk of seizures when taken with Ritalin
  • Iopamidol (Iopamidol-370, Isovue-128, Isovue-200, Isovue-250, Isovue-300, Isovue-370, Isovue-M-200, Isovue-M-300); increased risk of seizures when taken with Ritalin
    Isocarboxazid (Marplan); MAOIs may cause severe hypertension and possibly death if taken with Ritalin
  • Linezolid (Zyvox); MAOIs may cause severe hypertension and possibly death if taken with Ritalin
  • Magnesium sulfate/potassium sulfate/sodium sulfate (Suprep, Suprep Bowel Prep Kit); increased risk of seizures if taken with Ritalin
  • Methinamine/sodium biphosphate (Uro-Phosphate); increased risk of seizures if taken with Ritalin
  • Metrizamide; increased risk of seizures if taken with Ritalin
  • Phenelzine (Nardil); use of MAOIs with Ritalin may cause severe hypertension and possibly death
  • Pimozide (Orap); Ritalin may cause or aggravate motor or phonic tics; use of Ritalin in Tourette’s patients can make it difficult to tell if the tics are caused by Tourette’s or Ritalin; use of pimozide is contraindicated until patient has been withdrawn from Ritalin
  • Procarbazine (Matrulane); use of MAOIs with Ritalin may cause severe hypertension and possibly death
  • Selegiline (Atapryl, Carbex, Eldepryl, Emsam, Jumex, Selgene, Zelapar); use of MAOIs with Ritalin may cause severe hypertension and possibly death
  • Sodium phosphate/sodium biphosphate (Disposable Enema, Fleet Enema, Fleet Enema Extra, Fleet E-Z Prep, Fleet Phospho Soda, Osmo Prep, Pedia-Lax Enema, Phosphate Laxative, Visicol); increased risk of seizures when taken with Ritalin
  • Tramadol (ConZip, GenRx Tramadol, Rybix, Rybix ODT, Ryzolt, Tramahexal SR, Tramal, Tramal SR, Tramedo, Ultram, Ultram ER, Ultram ODT, Zamadol, Zydol); increased risk of seizures if used with Ritalin
  • Tranylcypromine (Parnate); use of MAOIs with Ritalin may cause severe hypertension and possible death

Ritalin and Antidepressants

Human pharmacologic studies conducted by various manufacturers of the class of antidepressants known as Selective Serotonin Reuptake Inhibitors (SSRIs) have found that the co-administration of Ritalin with SSRIs may alter the metabolism of the drug as well as the patient’s clinical response. Use of Ritalin with SSRIs is not contraindicated, but dosage may have to be adjusted. SSRI antidepressants include the following commonly prescribed drugs:

  • Escitalopram (Lexapro)
  • Fluoxetine (Prozac)
  • Sertraline (Zoloft)

Questions about Ritalin or Drug Interactions?

If you are taking Ritalin or another drug and are worried about potential interactions, please call our toll-free helpline. We can address drug misuse and abuse issues and help you find the safest and best options for ending abuse or addiction today. We are here 24 hours a day, so please call now.